SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis.

ABSTRACT:

Background

Angiogenesis, which plays a critical role in embryonic development and tissue repair, is controlled by a set of angiogenic signaling pathways. As a TF (transcription factor) belonging to the basic helix-loop-helix family, HEY (hairy/enhancer of split related with YRPW motif)-1 (YRPW motif, abbreviation of 4 highly conserved amino acids in the motif) has been identified as a key player in developmental angiogenesis. However, the precise mechanisms underlying HEY1's actions in angiogenesis remain largely unknown. Our previous studies have suggested a potential role for posttranslational SUMOylation in the dynamic regulation of vascular development and organization.

Methods

Immunoprecipitation, mass spectrometry, and bioinformatics analysis were used to determine the

SUBMITTER: Ren R 

PROVIDER: S-EPMC10872267 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature