Indoor particulate matter concentrations and air cleaner intervention association with biomarkers in former smokers with COPD.

ABSTRACT:

Background

Indoor pollutants have been associated with worse clinical outcomes in chronic obstructive pulmonary disease (COPD). Elevated biomarkers are associated with ambient pollution exposure, however the association with indoor pollution remains unclear.

Methods

Former smokers with spirometry-confirmed COPD were randomized to portable air cleaner or placebo. Indoor particulate matter (PM_2.5, PM₁₀, and ultrafine particles [UFP; PM_<0.1]) and biomarkers were measured longitudinally at pre-specified intervals and course PM fraction (PM_10-2.5) was calculated. Biomarkers were categorized based on associations with biologic mechanisms: inflammation (white blood cell count, interleukin [IL]-6, IL-8, IL-1β, tumor necrosis factor-α, inte

SUBMITTER: Fawzy A 

PROVIDER: S-EPMC10872275 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature