Systematic identification and characterization of five transcription factors mediating the oxidative stress response in Candida albicans.

ABSTRACT: Candida albicans is an opportunistic human fungal pathogen that causes superficial and systemic infections, particularly in immunocompromised individuals. In response to C. albicans infection, innate immune cells of the host produce and accumulate reactive oxygen species (ROS), which can lead to irreversible damage and apoptosis of fungal cells. Several transcription factors involved in this oxidative stress response have been identified; however, a systematic study to identify the transcription factors that mediate the oxidative stress response has not yet been conducted. Here, we screened a comprehensive transcription factor mutant library consisting of 211 transcription factor deletion mutant strains in the presence and absence of hydrogen peroxide (H₂O₂), a potent

SUBMITTER: Cui Y 

PROVIDER: S-EPMC10872297 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature