Sox9 is associated with two distinct patterning events during snake lung morphogenesis.

ABSTRACT: The evolutionary forces that allowed species adaptation to different terrestrial environments and led to great diversity in body shape and size required acquisition of innovative strategies of pattern formation during organogenesis. An extreme example is the formation of highly elongated viscera in snakes. What developmental patterning strategies allowed to overcome the space constraints of the snake's body to meet physiological demands? Here we show that the corn snake uses a Sox2-Sox9 developmental tool kit common to other species to generate and shape the lung in two phases. Initially Sox9 was found at low levels at the tip of the primary lung bud during outgrowth and elongation of the bronchial bud, without driving branching programs characteristic of mammalian lungs. Later, Sox9 induc

SUBMITTER: van Soldt BJ 

PROVIDER: S-EPMC10872300 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature