Plasma metabolite predictors of metabolic syndrome incidence and reversion.

ABSTRACT:

Background

Metabolic Syndrome (MetS) is a progressive pathophysiological state defined by a cluster of cardiometabolic traits. However, little is known about metabolites that may be predictors of MetS incidence or reversion. Our objective was to identify plasma metabolites associated with MetS incidence or MetS reversion.

Methods

The study included 1468 participants without cardiovascular disease (CVD) but at high CVD risk at enrollment from two case-cohort studies nested within the PREvención con DIeta MEDiterránea (PREDIMED) study with baseline metabolomics data. MetS was defined in accordance with the harmonized International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute criteria, which include meeting 3 or more threshold

SUBMITTER: Semnani-Azad Z 

PROVIDER: S-EPMC10872312 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature