Changes in graft outcomes in recipients <10 kg over 25 years of pediatric kidney transplantation in the United States.

ABSTRACT:

Background

Kidney transplant (KT) was initially associated with poor outcomes, especially in smaller recipients. However, pediatric transplantation has evolved considerably over time. We investigated the impact of weight at the time of transplant and whether outcomes changed over 25 years for <10 kg recipients.

Methods

Using the UNOS database, pediatric recipient outcomes were analyzed between 1/1/99 and 12/31/14. KT weight was stratified: <8.6 kg (mean weight of recipients <10 kg), 8.6-9.9 kg, 10-14.9 kg, 15-29.9 kg, and ≥30 kg. Outcomes in recipients <10 kg were then compared between 1990-1999 and 2000-2014.

Results

17 314 pediatric KT recipients were included; 518 (3%) had a transplant weight <10 kg. The highest rates of allograft loss and death were in recipients

SUBMITTER: Kilduff S 

PROVIDER: S-EPMC10872313 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature