Genetics of Parkinson's disease heterogeneity: A genome-wide association study of clinical subtypes.

ABSTRACT:

Introduction

Substantial heterogeneity between individual patients in the clinical presentation of Parkinson's disease (PD) has led to the classification of distinct PD subtypes. However, genetic susceptibility factors for specific PD subtypes are not well understood. Therefore, the present study aimed to investigate the genetics of PD heterogeneity by performing a genome-wide association study (GWAS) of PD subtypes.

Methods

A total of 799 PD patients were included and classified into tremor-dominant (TD) (N = 345), akinetic-rigid (AR) (N = 227), gait-difficulty (GD) (N = 82), and mixed (MX) (N = 145) phenotypic subtypes. After array genotyping and subsequent imputation, a total of 7,918,344 variants were assessed for association with each PD subtype using logistic regressio

SUBMITTER: Dulski J 

PROVIDER: S-EPMC10872335 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature