Performance of FRAX in older adults with frailty: the Framingham Heart Study.

ABSTRACT: We compared the performance of FRAX according to frailty status in 3554 individuals from the Framingham Study. During 10-year follow-up, 6.9% and 3.0% of participants with and without frailty experienced MOF. Discrimination profiles were lower in participants with frailty compared to those without, but they improved when FRAX included BMD.

Introduction

Frailty increases fracture risk. FRAX was developed to predict fractures but never validated in individuals with frailty. We aimed to compare the predictive performance of FRAX (v4.3) in individuals with and without frailty.

Methods

We conducted a cohort study using the Framingham Heart Study. Frailty was defined by the Fried phenotype. Major osteoporotic fractures (MOF) were ascertained from medical records during 10-year foll

SUBMITTER: Chattaris T 

PROVIDER: S-EPMC10872348 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature