Temporally non-regular patterns of deep brain stimulation (DBS) enhance assessment of evoked potentials while maintaining motor symptom management in Parkinson's disease (PD).

ABSTRACT:

Background

Traditional deep brain stimulation (DBS) at fixed regular frequencies (>100 Hz) is effective in treating motor symptoms of Parkinson's disease (PD). Temporally non-regular patterns of DBS are a new parameter space that may help increase efficacy and efficiency.

Objective

To compare the effects of temporally non-regular patterns of DBS to traditional regularly-spaced pulses.

Methods

We simultaneously recorded local field potentials (LFP) and monitored motor symptoms (tremor and bradykinesia) in persons with PD during DBS in subthalamic nucleus (STN). We quantified both oscillatory activity and DBS local evoked potentials (DLEPs) from the LFP.

Results

Temporally non-regular patterns were as effective as traditional pulse patterns in modulating motor sy

SUBMITTER: Palopoli-Trojani K 

PROVIDER: S-EPMC10872419 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature