Simultaneous tensile and shear measurement of the human cornea in vivo using S0- and A0-wave optical coherence elastography.

ABSTRACT: Understanding corneal stiffness is valuable for improving refractive surgery, detecting corneal abnormalities, and assessing intraocular pressure. However, accurately measuring the elastic properties, specifically the tensile and shear moduli that govern mechanical deformation, has been challenging. To tackle this issue, we have developed guided-wave optical coherence elastography that can simultaneously excite and analyze symmetric (S0) and anti-symmetric (A0) elastic waves in the cornea at around 10 kHz frequencies, enabling us to extract tensile and shear properties from measured wave dispersion curves. We verified the technique using elastomer phantoms and ex vivo porcine corneas and investigated the dependence on intraocular pressure using acoustoelastic theory that incorporates corne

SUBMITTER: Li GY 

PROVIDER: S-EPMC10872441 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature