Monocyte transcriptomic profile following EPA and DHA supplementation in men and women with low-grade chronic inflammation.

ABSTRACT:

Background

Recent data indicate considerable variability in response to very long chain omega-3 fatty acid supplementation on cardiovascular disease risk. This inconsistency may be due to differential effects of EPA vs DHA and/or sex-specific responses.

Methods

Sixteen subjects (eight men and eight women) 50-75 y and with low-grade chronic inflammation participated in a randomized controlled crossover trial comparing 3 g/d EPA, 3 g/d DHA, and placebo (3 g/d high oleic acid sunflower oil). Blood monocytes were isolated at the end of each phase for RNA-sequencing.

Results

Sex dimorphism in monocyte gene expression was observed, therefore, data for men and women were analyzed separately. 1088 genes were differentially expressed in men and 997 in women (p < 0.05). In both

SUBMITTER: So J 

PROVIDER: S-EPMC10872449 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature