Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants.

ABSTRACT: We used indirect brain mapping with virtual lesion tractography to test the hypothesis that the extent of white matter tract disconnection due to white matter hyperintensities (WMH) is associated with corresponding tract-specific cognitive performance decrements. To estimate tract disconnection, WMH masks were extracted from FLAIR MRI data of 481 cognitively intact participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) and used as regions of avoidance for fiber tracking in diffusion MRI data from 50 healthy young participants from the Human Connectome Project. Estimated tract disconnection in the right inferior fronto-occipital fasciculus, right frontal aslant tract, and right superior longitudinal fasciculus mediated the effects of WMH volume on executive function. Estimat

SUBMITTER: Taghvaei M 

PROVIDER: S-EPMC10872454 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature