Prenatal exposure to per- and polyfluoroalkyl substances and early childhood adiposity and cardiometabolic health in the Healthy Start study.

ABSTRACT:

Background/objectives

Observational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase childhood adiposity and cardiometabolic disruption. However, most previous studies have used weight-based measures that cannot distinguish between fat mass and lean mass. We evaluated associations of prenatal PFAS exposure with precisely measured body composition and cardiometabolic biomarkers in early childhood.

Subjects

373 eligible mother-infant pairs in the Healthy Start longitudinal cohort.

Methods

We used multiple linear regression and Bayesian kernel machine regression models to estimate associations between five PFAS in maternal mid-pregnancy serum, and early childhood adiposity via air displacement pleth

SUBMITTER: Starling AP 

PROVIDER: S-EPMC10872497 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature