Dynamic T 2 * relaxometry of hyperpolarized [1-¹³ C]pyruvate MRI in the human brain and kidneys.

ABSTRACT:

Purpose

This study aimed to quantify T 2 * $$ {T}_2^{\ast } $$ for hyperpolarized [1-¹³ C]pyruvate and metabolites in the healthy human brain and renal cell carcinoma (RCC) patients at 3 T.

Methods

Dynamic T 2 * $$ {T}_2^{\ast } $$ values were measured with a metabolite-specific multi-echo spiral sequence. The dynamic T 2 * $$ {T}_2^{\ast } $$ of [1-¹³ C]pyruvate, [1-¹³ C]lactate, and ¹³ C-bicarbonate was estimated in regions of interest in the whole brain, sinus vein, gray matter, and white matter in healthy volunteers, as well as in kidney tumors and the contralateral healthy kidneys in a separate group of RCC patients. T 2 * $$ {T}_2^{\ast } $$ was fit using a mono-exponential function; and metabolism was quantif

SUBMITTER: Liu X 

PROVIDER: S-EPMC10872504 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature