Mitochondrial morphology in the mouse adrenal cortex: Influence of chronic psychosocial stress.

ABSTRACT: Mitochondria within the adrenal cortex play a key role in synthesizing steroid hormones. The adrenal cortex is organized in three functionally specialized zones (glomerulosa, fasciculata, and reticularis) that produce different classes of steroid hormones in response to various stimuli, including psychosocial stress. Given that the functions and morphology of mitochondria are dynamically related and respond to stress, we applied transmission electron microscopy (TEM) to examine potential differences in mitochondrial morphology under basal and chronic psychosocial stress conditions. We used the chronic subordinate colony housing (CSC) paradigm, a murine model of chronic psychosocial stress. Our findings quantitatively define how mitochondrial morphology differs among each of the three adren

SUBMITTER: Vega-Vasquez T 

PROVIDER: S-EPMC10872515 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature