Double dissociation of dopamine and subthalamic nucleus stimulation on effortful cost/benefit decision making.

ABSTRACT: Deep brain stimulation (DBS) and dopaminergic therapy (DA) are common interventions for Parkinson's disease (PD). Both treatments typically improve patient outcomes, and both can have adverse side effects on decision making (e.g., impulsivity).^1,2 Nevertheless, they are thought to act via different mechanisms within basal ganglia circuits.³ Here, we developed and formally evaluated their dissociable predictions within a single cost/benefit effort-based decision-making task. In the same patients, we manipulated DA medication status and subthalamic nucleus (STN) DBS status within and across sessions. Using a series of descriptive and computational modeling analyses of participant choices and their dynamics, we confirm a double dissociation: DA medi

SUBMITTER: Pagnier GJ 

PROVIDER: S-EPMC10872531 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature