A time memory engram embedded in a light-entrainable circadian clock.

ABSTRACT: A longstanding mystery in chronobiology is the location and molecular mechanism of the food-entrainable oscillator (FEO).^1,2,3 The FEO is an enigmatic circadian pacemaker that controls food anticipatory activity (FAA). The FEO is implicated as a circadian oscillator that entrains to feeding time. However, the rhythmic properties of the FEO remain a mystery in part due to technical limitations in distinguishing FAA from locomotor activity controlled by the primary circadian pacemaker in the suprachiasmatic nucleus (SCN). To overcome this limitation, we used the Feeding Experimentation Device version 3 (FED3) to measure food-seeking, nose-poking behavior. When food availability was limited to 4 h at night, mice exhibited strong anticipat

SUBMITTER: Ehichioya DE 

PROVIDER: S-EPMC10872752 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature