Discovery, validation, and prodrug design of an ACE2 activator for treating bacterial infection-induced lung inflammation.

ABSTRACT: Exacerbated inflammatory responses can be detrimental and pose fatal threats to the host, as exemplified by the global impact of the COVID-19 pandemic, resulting in millions of fatalities. Developing novel drugs to combat the damaging effects of inflammation is essential for both preventive measures and therapeutic interventions. Accumulating evidence suggests that Angiotensin Converting Enzyme 2 (ACE2) possesses the ability to optimize inflammatory responses. However, the clinical applicability of this potential is limited due to the lack of dependable ACE2 activators. In this study, we conducted a screening of an FDA-approved drug library and successfully identified a novel ACE2 activator, termed H4. The activator demonstrated the capability to mitigate lung inflammation caused by bacter

SUBMITTER: Lu P 

PROVIDER: S-EPMC10872764 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature