Obesity, diabetes and their metabolic correlates in middle-aged adults with Down syndrome.

ABSTRACT:

Background

Obesity in adults without Down syndrome is associated with an adverse metabolic profile including high prevalence of pre-diabetes and diabetes, high levels of insulin, non-high-density lipoprotein (HDL) cholesterol, leptin and high-sensitivity C-reactive protein (hsCRP) and low levels of HDL and adiponectin. We examined whether obesity in middle-aged adults with Down syndrome is also related to an adverse metabolic profile.

Methods

This cross-sectional study included 143 adults with Down syndrome, with a mean age of 55.7 ± 5.7 years and 52.5% women. Body mass index (BMI) was classified as underweight (BMI < 18.5 kg/m² ), normal (BMI 18.5-24.9 kg/m² ), overweight (BMI 25-29.9 kg/m² ) and obese (BMI ≥ 30 kg/m² ). Diabetes

SUBMITTER: Luchsinger JA 

PROVIDER: S-EPMC10872834 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature