Longitudinal changes in body fat and metabolic complications in young people with perinatally acquired HIV.

ABSTRACT:

Background

The role of body fat on metabolic complications remains poorly understood in young people living with perinatally acquired HIV (YPHIV).

Objective

Our objective was to assess the association of changes in adiposity over 2 years with metabolic outcomes in YPHIV.

Methods

The PHACS Adolescent Master Protocol (AMP) study enrolled YPHIV from 2007 to 2009 across 15 US sites, including Puerto Rico. We included YPHIV aged 7-19 years with body composition data assessed by whole-body dual-energy X-ray absorptiometry (DXA) at baseline and 2 years later. Metabolic outcomes included homeostatic model assessment of insulin resistance (HOMA-IR) and non-high-density lipoprotein cholesterol (non-HDL-C). We fitted linear regression models to assess the association of increase

SUBMITTER: Dirajlal-Fargo S 

PROVIDER: S-EPMC10872855 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature