Inhibition of N-myristoyltransferase activity promotes androgen receptor degradation in prostate cancer.

ABSTRACT:

Background

Even though prostate cancer (PCa) patients initially respond to androgen deprivation therapy, some will eventually develop castration resistant prostate cancer (CRPC). Androgen receptor (AR) mediated cell signaling is a major driver in the progression of CRPC while only a fraction of PCa becomes AR negative. This study aimed to understand the regulation of AR levels by N-myristoyltransferase in PCa cells.

Methods

Two enantiomers, (1S,2S)- d-NMAPPD and (1R,2R)- d-NMAPPD (LCL4), were characterized by various methods (¹ H and ¹³ C NMR, UHPLC, high-resolution mass spectra, circular dichroism) and evaluated for the ability to bind to N-myristoyltransferase 1 (NMT1) using computational docking analysis. structure-activity relationship analysis of t

SUBMITTER: Alsaidan OA 

PROVIDER: S-EPMC10872856 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature