Thalamo-cortical circuits associated with trait- and state-repetitive negative thinking in major depressive disorder.

ABSTRACT:

Background

Repetitive negative thinking (RNT), often referred to as rumination in the mood disorders literature, is a symptom dimension associated with poor prognosis and suicide in major depressive disorder (MDD). Given the transdiagnostic nature of RNT, this study aimed to evaluate the hypothesis that neurobiological substrates of RNT in MDD may share the brain mechanisms underlying obsessions, particularly those involving cortico-striatal-thalamic-cortical (CSTC) circuits.

Methods

Thirty-nine individuals with MDD underwent RNT induction during fMRI. Trait-RNT was measured by the Ruminative Response Scale (RRS) and state-RNT was measured by a visual analogue scale. We employed a connectome-wide association analysis examining the association between RNT intensity with stria

SUBMITTER: Tsuchiyagaito A 

PROVIDER: S-EPMC10872862 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature