Vitamin D and monoclonal gammopathy of undetermined significance (MGUS) among U.S. Black women.

ABSTRACT:

Purpose

Risk factors for monoclonal gammopathy of undetermined significance (MGUS), the asymptomatic precursor to multiple myeloma, are largely unknown. We hypothesized that low vitamin D levels might be associated with higher MGUS prevalence in a national cohort of U.S. Black women.

Methods

We screened archived serum samples (collected 2014-2017) from 3896 randomly selected participants in the Black Women's Health Study ages 50-79 for evidence of MGUS; samples had been assayed for 25-hydroxyvitamin D [25(OH)D] shortly after blood draw. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between 25(OH)D level and MGUS status, adjusting for age, body mass index, and season of blood draw.

Results

We identified 3

SUBMITTER: Ruiz Lopez JN 

PROVIDER: S-EPMC10872902 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature