Use of overnight metyrapone test in suspected secondary adrenal insufficiency: A retrospective single centre-study.

ABSTRACT:

Objective

Overnight metyrapone test (OMT) is a dynamic test used to diagnose secondary adrenal insufficiency (SAI). Data on OMT use and its safety are scarce. We aimed to describe the indications and safety of outpatient OMT and compare OMT to the cosyntropin stimulation test (CST).

Design

Single-centre retrospective study of adult patients undergoing OMT between 1 April 2018 and 27 January 2023.

Measurements

OMT-related adverse events, post-OMT diagnosis of SAI, and OMT comparison to CST.

Results

OMT was performed in 114 patients (81, 71% women) at a median age of 48 (interquartile range 37-58). The pretest probability for SAI was low in 52 (46%) patients, moderate in 48 (42%) patients and high in 14 (12%) patients. Adverse events were reported in 7 (6.1%) pat

SUBMITTER: Saini J 

PROVIDER: S-EPMC10872941 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature