Mother's age at menarche is associated with odds of preterm delivery: A case-control study.

ABSTRACT:

Objective

There is a secular trend towards earlier age of menarche in the US and globally. Earlier age at menarche (AAM) has been associated with metabolic disorders that increase risk for preterm delivery (PTD), yet no studies in the US have investigated whether AAM influences risk of PTD. This study tested the hypothesis that AAM is associated with PTD.

Design

A case-control study.

Setting

The Boston Medical Center (BMC) in Boston, Massachusetts.

Population or sample

8264 mother-newborn dyads enrolled at birth at BMC between 1998 and 2019, of which 2242 mothers had PTD (cases) and 6022 did not have PTD (controls).

Methods

Multivariable-adjusted logistic regression models and restricted cubic splines were used to examine the association between AAM and

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10872971 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature