Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV.

ABSTRACT: Antiretroviral therapy (ART) has dramatically lengthened lifespan among people with HIV (PWH), but this population experiences heightened rates of inflammation-related comorbidities. HIV-associated inflammation is linked with an altered microbiome; whether such alterations precede inflammation-related comorbidities or occur as their consequence remains unknown. We find that ART-treated PWH exhibit depletion of gut-resident bacteria that produce short-chain fatty acids (SCFAs)-crucial microbial metabolites with anti-inflammatory properties. Prior reports establish that fecal SCFA concentrations are not depleted in PWH. We find that gut-microbiota-mediated SCFA production capacity is better reflected in serum than in feces and that PWH exhibit reduced serum SCFA, which associates with inflam

SUBMITTER: Sereti I 

PROVIDER: S-EPMC10872975 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature