Characterizing causal relationships of visceral fat and body shape on multiple sclerosis risk.

ABSTRACT:

Background

Epidemiologic studies have established obesity as a risk factor for multiple sclerosis (MS). These studies relied on body-mass index (BMI) and body size silhouettes as the primary measures of obesity. Unfortunately, the causal mechanisms through which obesity confers MS risk are not yet known.

Objectives

To investigate the causal effects of multiple specific measures of body fat on MS risk in populations of European descent, using Mendelian randomization (MR).

Methods

MR is a genetic instrumental variable analysis utilizing genome-wide association (GWA) summary statistics to infer causality between phenotypes. MR analyses were performed to investigate the relationships between seven measures of body fat (BMI, waist-hip ratio, visceral adipose tissue [VAT],

SUBMITTER: Misicka E 

PROVIDER: S-EPMC10873055 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature