Intranasal vaccination induces protective immunity against intranasal infection with virulent Francisella tularensis biovar A.

ABSTRACT: The inhalation of Francisella tularensis biovar A causes pneumonic tularemia associated with high morbidity and mortality rates in humans. Exposure to F. tularensis usually occurs by accident, but there is increasing awareness that F. tularensis may be deliberately released in an act of bioterrorism or war. The development of a vaccine against pneumonic tularemia has been limited by a lack of information regarding the mechanisms required to protect against this disease. Vaccine models for F. tularensis in inbred mice would facilitate investigations of the protective mechanisms and significantly enhance vaccine development. Intranasal vaccination with the attenuated live vaccine strain (LVS) of F. tularensis reproducibly protected BALB/c mice, but not C57BL/6 mice, against intranasal and su

SUBMITTER: Wu TH 

PROVIDER: S-EPMC1087315 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature