Systematic literature review of in vivo rat femoral defect models using biomaterials to improve the induced membrane technique: a comprehensive analysis.

ABSTRACT:

Purpose

The aim of this study was to conduct a systematic literature review analyzing the results of in vivo rat femoral defect models using biomaterials for improving the induced membrane technique (IMT).

Methods

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, the PubMed, Embase, and Web of Science databases were searched. Inclusion criteria were studies reporting results of the IMT in in vivo rat femoral critical-sized defect models using a biomaterial possibly combined with molecules. Methodologic quality was assessed with the Animal Research: Reporting In Vivo Experiments guidelines.

Results

Twenty studies met the inclusion criteria. Femoral stabilization with plate and screws was the most frequent. Histologic, biomecha

SUBMITTER: Saab M 

PROVIDER: S-EPMC10873241 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature