Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin†.

ABSTRACT: Placental chorion/labyrinth trophoblasts are energy demanding which is met by the mitochondrial oxidative phosphorylation. Exercise enhances placental development and mitochondrial biogenesis, but the underlying mechanisms remain poorly understood. To address, female C57BL/6 J mice were randomly assigned into two groups: a control group and an exercise (EX) group. All animals were acclimated to treadmill exercise for 1 week before mating, but only the EX group was subjected to daily exercise during pregnancy from embryonic day (E) 1.5 to E16.5. Placenta were collected at E18.5 for biochemical and histochemical analyses, and primary trophoblast cells were isolated from the E18.5 placenta for further analyses. The data showed that exercise during pregnancy promoted the expression of syncytio

SUBMITTER: Chae SA 

PROVIDER: S-EPMC10873274 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature