Role of Hemigraphis alternata in wound healing: metabolomic profiling and molecular insights into mechanisms.

ABSTRACT: Hemigraphis alternata (H. alternata), commonly known as Red Flame Ivy, is widely recognized for its wound healing capabilities. However, the pharmacologically active plant components and their mechanisms of action in wound healing are yet to be determined. This study presents the mass spectrometry-based global metabolite profiling of aqueous and ethanolic extract of H. alternata leaves. The analysis identified 2285 metabolites from 24,203 spectra obtained in both positive and negative polarities. The identified metabolites were classified under ketones, carboxylic acids, primary aliphatic amines, steroids and steroid derivatives. We performed network pharmacology analysis to explore metabolite-protein interactions and identified 124 human proteins as targets for H. alternata metabolites. A

SUBMITTER: Devasahayam Arokia Balaya R 

PROVIDER: S-EPMC10873326 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature