TM4SF19 controls GABP-dependent YAP transcription in head and neck cancer under oxidative stress conditions.

ABSTRACT: Tobacco and alcohol are risk factors for human papillomavirus-negative head and neck squamous cell carcinoma (HPV^- HNSCC), which arises from the mucosal epithelium of the upper aerodigestive tract. Notably, despite the mutagenic potential of smoking, HPV^- HNSCC exhibits a low mutational load directly attributed to smoking, which implies an undefined role of smoking in HPV^- HNSCC. Elevated YAP (Yes-associated protein) mRNA is prevalent in HPV^- HNSCC, irrespective of the YAP gene amplification status, and the mechanism behind this upregulation remains elusive. Here, we report that oxidative stress, induced by major risk factors for HPV^- HNSCC such as tobacco and alcohol, promotes YAP transcription via TM4SF19 (transm

SUBMITTER: Shin E 

PROVIDER: S-EPMC10873613 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature