Brain energy metabolism is optimized to minimize the cost of enzyme synthesis and transport.

ABSTRACT: The energy metabolism of the brain is poorly understood partly due to the complex morphology of neurons and fluctuations in ATP demand over time. To investigate this, we used metabolic models that estimate enzyme usage per pathway, enzyme utilization over time, and enzyme transportation to evaluate how these parameters and processes affect ATP costs for enzyme synthesis and transportation. Our models show that the total enzyme maintenance energy expenditure of the human body depends on how glycolysis and mitochondrial respiration are distributed both across and within cell types in the brain. We suggest that brain metabolism is optimized to minimize the ATP maintenance cost by distributing the different ATP generation pathways in an advantageous way across cell types and potentially also a

SUBMITTER: Gustafsson J 

PROVIDER: S-EPMC10873630 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature