Diverse macrophage populations contribute to distinct manifestations of human cutaneous graft-versus-host disease.

ABSTRACT:

Background

Graft-versus-host disease (GvHD) is a major life-threatening complication of allogeneic haematopoietic stem cell transplantation (HSCT), limiting the broad application of HSCT for haematological malignancies. Cutaneous GvHD is described as a post-transplant inflammatory reaction by skin-infiltrating donor T cells and remaining recipient tissue-resident memory T cells. Despite the major influence of lymphocytes on GvHD pathogenesis, the complex role of mononuclear phagocytes (MNPs) in tissues affected by GvHD is increasingly appreciated.

Objectives

To characterize the identity, origin and functions of MNPs in patients with acute cutaneous GvHD.

Methods

Using single-cell RNA sequencing and multiplex tissue immunofluorescence, we identified an increased abunda

SUBMITTER: Strobl J 

PROVIDER: S-EPMC10873647 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature