An Injectable silk-based hydrogel as a novel biomineralization seedbed for critical-sized bone defect regeneration.

ABSTRACT: The healing process of critical-sized bone defects urges for a suitable biomineralization environment. However, the unsatisfying repair outcome usually results from a disturbed intricate milieu and the lack of in situ mineralization resources. In this work, we have developed a composite hydrogel that mimics the natural bone healing processes and serves as a seedbed for bone regeneration. The oxidized silk fibroin and fibrin are incorporated as rigid geogrids, and amorphous calcium phosphate (ACP) and platelet-rich plasma serve as the fertilizers and loam, respectively. Encouragingly, the seedbed hydrogel demonstrates excellent mechanical and biomineralization properties as a stable scaffold and promotes vascularized bone regeneration in vivo. Additionally, the seedbed serves a succinate-li

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10873665 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature