P2X7 receptor inhibition prevents atrial fibrillation in rodent models of depression.

ABSTRACT:

Aims

Depression, the most prevalent psychiatric disorder, is associated with the occurrence and development of atrial fibrillation (AF). P2X7 receptor (P2X7R) activation participates in the development of depression, but little attention has been given to its role in AF. This study was to investigate the effects of P2X7R on AF in depression models.

Methods and results

Lipopolysaccharide (LPS) and chronic unpredictable stress (CUS) were carried out to induce depression in rodents. Behavioural assessments, atrial electrophysiological parameters, electrocardiogram (ECG) parameters, western blot, and histology were performed. Atrial fibrillation inducibility was increased in both LPS- and CUS-induced depression, along with the up-regulation of P2X7R in atria. CUS facilitated atr

SUBMITTER: Ye T 

PROVIDER: S-EPMC10873709 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature