APOE ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation.

ABSTRACT:

Importance

Intracerebral hemorrhage (ICH) is a serious complication of brain arteriovenous malformation (AVM). Apolipoprotein E (APOE) ε4 is a well-known genetic risk factor for ICH among persons without AVM, and cerebral amyloid angiopathy is a vasculopathy frequently observed in APOE ε4 carriers that may increase the risk of ICH.

Objective

To assess whether APOE ε4 is associated with a higher risk of ICH in patients with a known AVM.

Design, setting, and participants

This cross-sectional study including 412 participants was conducted in 2 stages (discovery and replication) using individual-level data from the UK Biobank (released March 2012 and last updated October 2023) and the All of Us Research Program (commenced on May 6, 2018, with its latest update provided in

SUBMITTER: Renedo D 

PROVIDER: S-EPMC10873768 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature