Bridge: A New Algorithm for Rooting Orthologous Genes in Large-Scale Evolutionary Analyses.

ABSTRACT: Orthology information has been used for searching patterns in high-dimensional data, allowing transferring functional information between species. The key concept behind this strategy is that orthologous genes share ancestry to some extent. While reconstructing the history of a single gene is feasible with the existing computational resources, the reconstruction of entire biological systems remains challenging. In this study, we present Bridge, a new algorithm designed to infer the evolutionary root of orthologous genes in large-scale evolutionary analyses. The Bridge algorithm infers the evolutionary root of a given gene based on the distribution of its orthologs in a species tree. The Bridge algorithm is implemented in R and can be used either to assess genetic changes across the evoluti

SUBMITTER: Campos LRS 

PROVIDER: S-EPMC10873778 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature