Assessing the relationship between gut microbiota and endometriosis: a bidirectional two-sample mendelian randomization analysis.

ABSTRACT:

Background

An increasing body of observational studies have indicated an association between gut microbiota and endometriosis. However, the causal relationship between them is not yet clear. In this study, we employed Mendelian randomization method to investigate the causal relationship between 211 gut microbiota taxa and endometriosis.

Methods

Independent genetic loci significantly associated with the relative abundance of 211 gut microbiota taxa, based on predefined thresholds, were extracted as instrumental variables. The primary analytical approach employed was the IVW method. Effect estimates were assessed primarily using the odds ratio and 95% confidence intervals. Supplementary analyses were conducted using MR-Egger regression, the weighted median method, the simple m

SUBMITTER: Dang C 

PROVIDER: S-EPMC10873948 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature