Effective density of inhaled environmental and engineered nanoparticles and its impact on the lung deposition and dosimetry.

ABSTRACT:

Background

Airborne environmental and engineered nanoparticles (NPs) are inhaled and deposited in the respiratory system. The inhaled dose of such NPs and their deposition location in the lung determines their impact on health. When calculating NP deposition using particle inhalation models, a common approach is to use the bulk material density, ρ_b, rather than the effective density, ρ_eff. This neglects though the porous agglomerate structure of NPs and may result in a significant error of their lung-deposited dose and location.

Results

Here, the deposition of various environmental NPs (aircraft and diesel black carbon, wood smoke) and engineered NPs (silica, zirconia) in the respiratory system of humans and mice is calculated using the Multiple-Path Pa

SUBMITTER: Lizonova D 

PROVIDER: S-EPMC10874077 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature