Modulation of expression of the ToxR regulon in Vibrio cholerae by a member of the two-component family of response regulators.

ABSTRACT: The ToxRS system in Vibrio cholerae plays a central role in the modulation of virulence gene expression in response to environmental stimuli. An integration of multiple signalling inputs mediated by ToxR, -S, and -T controls virulence gene expression leading to cholera toxin (CT) production. Recently, we identified a new virulence locus, varA (virulence associated regulator), in classical V. cholerae O1 that positively controls transcription of tcpA, the major subunit of the toxin-coregulated pilus (TCP) and the production of CT, two key factors in cholera pathogenesis. The varA locus is a homolog of gacA (originally described for the soil organism Pseudomonas fluorescens), which encodes a conserved global regulator belonging to the family of two-component signal transducing molecules. Gac

SUBMITTER: Wong SM 

PROVIDER: S-EPMC108741 | biostudies-literature | 1998 Dec

REPOSITORIES: biostudies-literature