A Novel Necroptosis-Related Signature Can Predict Prognosis and Chemotherapy Sensitivity in Multiple Myeloma.

ABSTRACT:

Background

Necroptosis is an inflammatory cell death mode, and its association with multiple myeloma (MM) remains unclear.

Methods

This prospective study first analyzed the association between necroptosis-related signature as well as prognosis and chemotherapy sensitivity in MM using the necroptosis score. Consensus clustering was used to identify necroptosis-related molecular clusters. Least absolute shrinkage and selection operator analysis and multivariate Cox regression analysis were performed to establish the prognostic model of necroptosis-related genes (NRGs).

Results

A high necroptosis score was associated with poor prognosis and abundant immune infiltration. Two molecular clusters (clusters A and B) significantly differed in terms of prognosis and tumor micro

SUBMITTER: Jiang JY 

PROVIDER: S-EPMC10874153 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature