Weight Gain After Antiretroviral Therapy Initiation and Subsequent Risk of Metabolic and Cardiovascular Disease.

ABSTRACT:

Background

Weight gain following initiation of antiretroviral therapy (ART) is common. We assessed the impact of changes in weight in the year following ART initiation with subsequent cardiometabolic disease among AIDS Clinical Trials Group (ACTG) participants.

Methods

Linear regression models were fit to examine the association between change in weight/waist circumference (WC) in weeks 0-48 and change in metabolic parameters in weeks 0-48 and 48-96. Cox proportional hazard models were fit to examine the association between changes in weight/WC in weeks 0-48 and diabetes mellitus (DM), metabolic syndrome, or cardiometabolic and cardiovascular events after week 48.

Results

Participants (N = 2624) were primarily male (81%) and non-White (60%). Mean weight gain from 0-48

SUBMITTER: Bares SH 

PROVIDER: S-EPMC10874261 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature