Early Improved Functional Outcomes in Head and Neck Cancer Patients with Primary Tumor Detection.

ABSTRACT:

Objectives

We characterize functional outcomes in head and neck cancer of unknown primary (CUP) based on primary site identification.

Methods

In this retrospective study, CUP cases were categorized as known primaries (KP) if a tumor was localized after diagnostic workup or persisting unknown primaries (UP). Age, sex, HPV status, diagnostic methods, and treatments regimens were collected. Pretreatment and short-term posttreatment (3-6 months after completion of treatment) weights, PHQ-9, Eating Assessment Tool (EAT-10), and Voice Handicap Index (VHI-10) scores were compared between UP and KP.

Results

Among 67 CUP patients, 35 (52.2%) had identified primaries (91.4% oropharyngeal and 8.6% nasopharyngeal). KP patients were younger (58 vs. 64, p = 0.04) and more likely to

SUBMITTER: Kalavacherla S 

PROVIDER: S-EPMC10874284 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature