PCDH8 is a novel prognostic biomarker in thyroid cancer and promotes cell proliferation and viability.

ABSTRACT: Protocadherin 8 (PCDH8), a calcium-dependent transmembrane protein in the protocadherin family, regulates cell adhesion and signal transduction. While some studies have provided indirect evidence that PCDH8 has cancer-promoting properties, this association is controversial. In particular, its involvement in thyroid cancer (THCA) remains unclear. We aimed to elucidate the role of PCDH8 in THCA using bioinformatic analysis. Subsequently, the results were experimentally validated. The analysis conducted using the R programming language and online web tools explored PCDH8 expression levels, prognostic, and clinical implications, and its relationship with the tumor immune microenvironment in THCA. Furthermore, we examined the association between PCDH8 and co-expressed genes, highlighting their

SUBMITTER: Yang R 

PROVIDER: S-EPMC10874333 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature