Protective efficacy of a Zika purified inactivated virus vaccine candidate during pregnancy in marmosets.

ABSTRACT: Zika virus (ZIKV) infection during pregnancy poses significant threats to maternal and fetal health, leading to intrauterine fetal demise and severe developmental malformations that constitute congenital Zika syndrome (CZS). As such, the development of a safe and effective ZIKV vaccine is a critical public health priority. However, the safety and efficacy of such a vaccine during pregnancy remain uncertain. Historically, the conduct of clinical trials in pregnant women has been challenging. Therefore, clinically relevant animal pregnancy models are in high demand for testing vaccine efficacy. We previously reported that a marmoset pregnancy model of ZIKV infection consistently demonstrated vertical transmission from mother to fetus during pregnancy. Using this marmoset model, we also showe

SUBMITTER: Kim IJ 

PROVIDER: S-EPMC10874403 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature