Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder.

ABSTRACT: The molecular events underlying the development, manifestation, and course of schizophrenia, bipolar disorder, and major depressive disorder span from embryonic life to advanced age. However, little is known about the early dynamics of gene expression in these disorders due to their relatively late manifestation. To address this, we conducted a secondary analysis of post-mortem prefrontal cortex datasets using bioinformatics and machine learning techniques to identify differentially expressed gene modules associated with aging and the diseases, determine their time-perturbation points, and assess enrichment with expression quantitative trait loci (eQTL) genes. Our findings revealed early, mid, and late deregulation of expression of functional gene modules involved in neurodevelopment, plas

SUBMITTER: Arakelyan A 

PROVIDER: S-EPMC10874418 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature