Iron-catalyzed fluoroalkylative alkylsulfonylation of alkenes via radical-anion relay.

ABSTRACT: Transition metal-catalyzed reductive difunctionalization of alkenes with alkyl halides is a powerful method for upgrading commodity chemicals into densely functionalized molecules. However, super stoichiometric amounts of metal reductant and the requirement of installing a directing group into alkenes to suppress the inherent β-H elimination bring great limitations to this type of reaction. We demonstrate herein that the difunctionalization of alkenes with two different alkyl halides is accessible via a radical-anion relay with Na₂S₂O₄ as both reductant and sulfone-source. The Na₂S₂O₄ together with the electron-shuttle catalyst is crucial to divert the mechanistic pathway toward the formation of alkyl sulfone anion instead o

SUBMITTER: Hou X 

PROVIDER: S-EPMC10874428 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature