Causal associations between leisure sedentary behaviors and sleep status with frailty: insight from Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested that sedentary behaviors and sleep status are associated with frailty. However, it remains unclear whether these associations are causal.

Methods

Using summary statistics from genome-wide association studies, we evaluated the causal effect of modifiable risk factors, including leisure sedentary behaviors and sleep status on the frailty index (FI) using two-sample univariable and multivariable Mendelian randomization (MR) analyses. Genetic correlations were tested between the correlated traits.

Results

We identified potential causal associations between the time spent watching television (β = 0.26, 95% confidence interval [CI]: 0.21-0.31, P = 3.98e-25), sleep duration (β = -0.18, 95%CI: -0.26, -0.10; P = 6.04e-06), and da

SUBMITTER: Li C 

PROVIDER: S-EPMC10874533 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature