Diffuse large B-cell lymphoma: the significance of CD8⁺ tumor-infiltrating lymphocytes exhaustion mediated by TIM3/Galectin-9 pathway.

ABSTRACT:

Background

Overexpression of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is related to the exhaustion of CD8⁺ tumor-infiltrating lymphocytes (TILs) in diffuse large B-cell lymphoma (DLBCL). However, the mechanism of TIM3-mediated CD8⁺TILs exhaustion in DLBCL remains poorly understood. Therefore, we aimed to clarify the potential pathway involved in TIM3-mediated CD8⁺TILs exhaustion and its significance in DLBCL.

Methods

The expression of TIM3 and its correlation with CD8⁺TILs exhaustion, the key ligand of TIM3, and the potential pathway of TIM3-mediated CD8⁺TILs exhaustion in DLBCL were analyzed using single-cell RNA sequencing and validated by RNA sequencing. The biological significance of TIM3-re

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC10874540 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature